A pH-dependent protein kinase cascade regulates divergent differentiation of Leishmania in the sand fly.
Laryssa Vanessa de Liz, Jovana Sádlová, Barbora Bečvářová, J.A. Brannigan, Sarah Jayne Forrester, Charlotte Hughes, Adam Dowle, Chris Taylor, Anthony J. Wilkinson, Petr Volf, Jeremy Charles Mottram, Nicola Baker
This study identifies a pH-dependent kinase cascade in Leishmania that regulates differentiation into infectious stages, revealing key pathways for acid adaptation and transmission.
bioRxiv · Sep 16, 2026 · PreprintMicrobiology