MicrobiologybioRxivPreprint
Clade-defining mutations in human H1N1 hemagglutinin protein from 2021-2023 have opposing effects on in vitro fitness and antigenic drift
Nicholas J. Swanson, Jyothsna Girish, Madeline Yunker…·Andrew S Pekosz
This study identifies clade-defining mutations in H1N1 hemagglutinin that improve viral fitness but reduce neutralization by vaccine-induced antibodies, revealing an evolutionary trade-off between replication and immune evasion.
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