Cell BiologybioRxiv
Post-Transplant Administration of G-CSF Impedes Engraftment of Gene Edited Human Hematopoietic Stem Cells by Exacerbating the p53-Mediated DNA Damage Response
Daisuke Araki, Vicky Chen, Neelam Redekar…·Andre Larochelle
This study shows that post-transplant G-CSF administration impairs engraftment of CRISPR-edited HSPCs by worsening the p53 DNA damage response, but not unedited or lentiviral-transduced HSPCs.
DOI 10.1016/j.stem.2024.10.013