BioinformaticsbioRxivPreprint
simCRISPR: Modeling experimental complexity in pooled CRISPR screens
Zhaohan Zhu, Xiaoru Dong, Chanhee Kim…·Rhonda L. Bacher
The paper develops simCRISPR, a simulation framework for pooled CRISPR screens, evaluates normalization strategies for detecting gene-by-environment interactions, and shows improved results with safe-harbor normalization.
DOI 10.64898/2026.05.14.725042