Molecular BiologyeLifePeer-reviewed
UBE2G1 Governs the Destruction of Cereblon Neomorphic Substrates
Gang Lu, Stephanie Weng, Mary E. Matyskiela…·Mark Rolfe
The paper identifies UBE2G1 as a critical E2 ubiquitin-conjugating enzyme required for the degradation of CRL4CRBN neomorphic substrates, showing its role in drug resistance and potential for overcoming it with next-generation compounds.
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