eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules
Stephen Connor Purdy, Kate Matlin, Christopher Alderman, Amber Baldwin, Natasha Shrivastava, Goksu Sarioglu, Somnath Dutta, Kristofor J. Webb, Arthur R. Wolin, Dillon P. Boulton, Annika L. Gustafson, Jyoti Kapali, John David Landua, Michael T. Lewis, M. Cecilia Caino, , Neelanjan Mukherjee
The paper identifies eIF3d and eIF3e as mediators of hypoxia-induced translational control and shows that small molecules can inhibit this process.
Cell Reports · Dec 1, 2025Peer-reviewedCancer Biology