Austin E. Gillen

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

scExploreR provides a user-friendly platform for non-programmers to analyze multimodal single-cell data with customizable plots and seamless handling of different input formats.

This study identifies IRF2BP2 cytoplasmic sequestration by MCL1 as a mechanism driving venetoclax and azacitidine resistance in AML through ACSL1 derepression.

This paper evaluates avidity sequencing for single-cell RNA-seq, showing it accurately sequences through homopolymers and improves alignment workflows.

This study identifies antigen-driven CD8+ T cell clonal expansion in human and mouse MASH, showing their activation and functional differentiation in liver disease.

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

The paper shows that inhibiting NMD in FSHD leads to widespread production of truncated RNA-binding proteins, some of which are toxic and can be detected in patient samples.

The paper introduces scraps, a pipeline for high-resolution APA detection in scRNA-seq, showing it outperforms existing methods and enables assessment of internal priming events.

LABRAT quantifies alternative polyadenylation (APA) and identifies its associations with RNA localization, transcription speed, cancer survival, and RNA-binding protein regulation.

clustifyr assigns cell types to scRNA-seq clusters using diverse reference data and provides tools for exploratory analysis.

The paper shows Prdm8 regulates the switch from motor neuron to oligodendrocyte production in zebrafish spinal cord by modulating Shh signaling.

The paper develops a method to recover and analyze targeted transcriptome subsets from scRNA-seq libraries, improving sequencing depth and gene detection.

The paper quantifies A-to-I RNA editing in hibernating ground squirrels and finds cold-induced editing sites that may provide neuroprotection during torpor.