Author

Christopher Kline

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Assay:clinical cohort / trial· 1 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Zandrea AmbroseiD· 3 shared Collin R. DiedrichiD· 2 shared Edwin Klein· 2 shared Jessica MedranoiD· 2 shared Pauline A MaielloiD· 2 shared Philana Ling LiniD· 2 shared Daniel J. Fillmore· 1 shared Forrest F. HopkinsiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

Zandrea AmbroseORCID

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Author profile →

3 papers

Recent·Most cited

SIV infection disrupts the spatial cellular and communication networks of pulmonary granulomas during SIV/Mtb co-infection

Jessica Medrano, Persis S Sunny, Collin R. Diedrich, Pauline A Maiello, Christopher Kline, Tara W. Rutledge, Edwin Klein, Joshua T. Mattila, Jishnu Das, Zandrea Ambrose, Philana Ling Lin

This study examines how SIV infection affects spatial cellular organization and communication in pulmonary granulomas during SIV/Mtb co-infection, showing disrupted patterns not fully restored by ART.

JCI Insight · Sep 24, 2026Peer-reviewedImmunology

Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques

Collin R. Diedrich, Tara Rutledge, Janelle L. Gleim, Christopher Kline, Pauline A Maiello, Jessica Medrano, Henry Jacob Borish, Harris B. Chishti, Justin Gaines, Edwin Klein, Forrest F. Hopkins, Jacob Klein, Daniel J. Fillmore, Kara B. Kracinovsky, Jaime A. Tomko, , Philana Ling Lin

This study shows that antiretroviral treatment (ART) does not prevent extrapulmonary tuberculosis in SIV/Mtb co-infected macaques, despite suppressing SIV replication.

JCI Insight · Feb 23, 2026Peer-reviewedImmunology

Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission

Hannah L. Fischer, Shanmugapriya Shanmugapriya, Christopher Kline, William Paul Duprex, Kevin R. McCarthy, Simon C. Watkins, James F. Conway, Zandrea Ambrose

This study shows that deleting the Envelope gene in SARS-CoV-2 increases cell surface Spike protein and cell-to-cell transmission, reducing neutralizing antibody inhibition.

bioRxiv · May 20, 2025 · PreprintMicrobiology