Author

Edwin Klein

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:non-human primate· 2 Research Focus:cell-cell communication· 1 Assay:clinical cohort / trial· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Christopher Kline· 2 shared Collin R. DiedrichiD· 2 shared Jennifer Schober· 2 shared Jessica MedranoiD· 2 shared Pauline A MaielloiD· 2 shared Philana Ling LiniD· 2 shared Zandrea AmbroseiD· 2 shared Alanna Callendrello· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Christopher Kline

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Protection against disseminated disease following reinfection with Mycobacterium tuberculosis requires CD8+ lymphocytes

Andrew W Simonson, Michael C Chao, E Grace Bothwell, Feng Shan, Mark A Rodgers, Luke E Hood, Forrest Hopkins, Michael R Chase, Alanna Callendrello, Alexander A Smith, Ryan J Kelly, Cassaundra L Ameel, Edwin Klein, Jennifer Schober, Kara Kracinovsky, , JoAnne L Flynn

This study shows that CD8+ lymphocytes are essential for preventing Mtb dissemination during reinfection, highlighting their non-redundant role in concomitant immunity.

bioRxiv · Nov 3, 2026 · PreprintImmunology

SIV infection disrupts the spatial cellular and communication networks of pulmonary granulomas during SIV/Mtb co-infection

Jessica Medrano, Persis S Sunny, Collin R. Diedrich, Pauline A Maiello, Christopher Kline, Tara W. Rutledge, Edwin Klein, Joshua T. Mattila, Jishnu Das, Zandrea Ambrose, Philana Ling Lin

This study examines how SIV infection affects spatial cellular organization and communication in pulmonary granulomas during SIV/Mtb co-infection, showing disrupted patterns not fully restored by ART.

JCI Insight · Sep 24, 2026Peer-reviewedImmunology

Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques

Collin R. Diedrich, Tara Rutledge, Janelle L. Gleim, Christopher Kline, Pauline A Maiello, Jessica Medrano, Henry Jacob Borish, Harris B. Chishti, Justin Gaines, Edwin Klein, Forrest F. Hopkins, Jacob Klein, Daniel J. Fillmore, Kara B. Kracinovsky, Jaime A. Tomko, , Philana Ling Lin

This study shows that antiretroviral treatment (ART) does not prevent extrapulmonary tuberculosis in SIV/Mtb co-infected macaques, despite suppressing SIV replication.

JCI Insight · Feb 23, 2026Peer-reviewedImmunology