Impaired glycolysis in bone underlies age-related bone loss in mice
Fangfang Song, Tyler Marmo, Won Dong Lee, Jasmin Koehnken Sawall, Chao Song, Xueyang Liao, Xing Ji, Karthi Chellappa, Melanie R. McReynolds, Joseph A. Baur, Christopher Thom, Fanxin Long
This study shows that impaired glycolysis in bone tissue of aged mice leads to reduced bone formation, and that enhancing glycolysis can improve bone mass.
bioRxiv · Oct 6, 2026 · PreprintPhysiology