Melanie R. McReynolds

This study compares multi-omics data from yeast-derived extracellular vesicles to show conserved membrane architecture and strain-specific metabolic cargo enrichment.

This study shows that β-catenin activation in liver cancer cells reduces mitochondrial pyruvate carrier expression and shifts metabolism from carbohydrate to fatty acid oxidation.

This study shows that impaired glycolysis in bone tissue of aged mice leads to reduced bone formation, and that enhancing glycolysis can improve bone mass.

This study examines metabolomic, lipidomic, and enterohormone changes during progression from MASLD to MASH in mice, identifying cholic acid elevation and altered enteroendocrine hormone levels.

This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.

This study identifies microbial-specific Trp metabolism signatures in colitis by analyzing metabolites across multiple compartments in mice treated with DSS and antibiotics.

This study identifies glucose and oxygen as critical metabolic factors influencing HIV-1 latency reversal, showing that glucose fuels histone lactylation and chromatin accessibility at the HIV promoter.

This study uses metabolomic profiling in Drosophila melanogaster to show that selection for early reproduction leads to repeatable metabolic changes and a reliable predictor of biological age.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study shows that inhibiting purine biosynthesis with mizoribine prevents weight gain and improves metabolic health in mice on a high-fat diet by increasing thermogenesis and reducing food intake.

This study shows that inhibiting IDO1 restores hippocampal glucose metabolism and rescues cognition in Alzheimer's disease models.

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

This study shows that NMN supplementation in aged mice increases kidney inflammation and uremic toxins, suggesting age-specific risks of NAD+ boosting supplements.

This study shows that TREM1 deficiency prevents age-related myeloid metabolic changes and cognitive decline in Alzheimer's disease models.

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

The paper introduces NetID, a global network optimization method for annotating untargeted metabolomics data, identifying novel metabolites in yeast and mouse datasets.

This study identifies ZIP-5/bZIP transcription factor regulation of folate metabolism as critical for aging axon regeneration, showing dietary folic acid improves regeneration in C. elegans and zebrafish.

This study shows that mitochondrial sirtuins sir-2.2 and sir-2.3 in C. elegans extend lifespan when fed E. coli OP50 but not HT115, with diet-dependent changes in oxidative stress gene expression.

This study uses a C. elegans model to show that adenylosuccinate lyase deficiency causes distinct neuromuscular and reproductive defects with different metabolic causes.