Cell Surface Sialoglycan Engineering Through Exogenous mRNA
Vanessa Affe, Qingyu Shi, Olivia Mann-Delany, David Alvarez, Landon J. Edgar, Haissi Cui
This paper develops an mRNA-based platform to transiently control sialoglycan biosynthesis on human cells by delivering sialyltransferase enzymes, showing increased surface presentation of specific sialoglycans with minimal off-target effects.
bioRxiv · Sep 9, 2026 · PreprintBioengineering