BioengineeringbioRxivPreprint
De Novo Negatively Charged Binders Targeting MMLVRT Nucleic Acid Binding Sites Overcome Stability-Activity Trade-offs
Yibo Zhu, Hongwei Liu, Fang Qu…·Tao Li
This paper designs negatively charged binders that enhance the stability of MMLV RT without affecting its activity, overcoming stability-activity trade-offs.
DOI 10.1101/2025.03.15.643416