Jean‐Paul Concordet

This study identifies that loss of Polθ reduces unwanted mutations in zebrafish prime editing, enabling error-free and efficient genome editing.

This study compares immune responses to AAV-delivered CRISPR-Cas9 and RNP-delivered CRISPR-Cas9 in the retina, finding persistent inflammation with AAV and transient inflammation with RNP.

The paper compares CRISPR/Cas9 gene editing efficiency in retinal organoids, HEK293T cells, and mouse models, finding retinal organoids better mirror in vivo editing outcomes.

The paper shows that genotoxic stress triggers nuclear import of EXD2 to resolve RNA-DNA hybrids at stalled RNAPII, preventing transcription-replication conflicts and maintaining genome stability.

This study delivers Cas9 or base editor RNP complexes directly to retinal cells, achieving gene editing in photoreceptors and RPE, but with toxicity at high concentrations.

This study evaluates the safety and efficacy of CRISPR/Cas9-mediated HbF reactivation in sickle cell disease by testing it in patient-derived HSPCs and shows it is effective but has off-target effects.

The paper identifies a novel tardigrade-specific DNA binding protein, TDR1, that enhances resistance to ionizing radiation in human cells.

This study shows that mitochondrial defects in desmin-mutated cardiomyocytes contribute to cardiomyopathy and can be reversed by transferring normal mitochondria.

This paper introduces a near PAM-less base editor that enables efficient point mutation introduction in zebrafish for disease modeling.

The paper demonstrates the use of base editors to generate precise point mutations in zebrafish for studying developmental signaling and human pathologies.

The paper presents a protocol for designing, executing, and analyzing CRISPR genome editing experiments using CRISPOR and CRISPResso.