ZBP1 Senses Splicing Aberration through Z-RNA to promote Cell Death
Zhang-Hua Yang, Puqi Wu, Bo-Xin Zhang, Congrong Yang, Jia Huang, Lei Wu, Shaoyu Guo, Yuenan Zhou, Yuanhui Mao, Yafei Yin, Xiurong Wu, Pu Cheng, Baizhou Li, Rongbin Zhou, Han‐Ming Shen, , Wei Mo
This study shows that spliceosome inhibition generates Z-RNA, sensed by ZBP1 to trigger necroptosis in response to splicing aberrations.
Molecular Cell · Apr 22, 2025Peer-reviewedCell Biology