Wei Mo

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.

This study shows that spliceosome inhibition generates Z-RNA, sensed by ZBP1 to trigger necroptosis in response to splicing aberrations.

This paper identifies a ZBP1 isoform (ZBP1-S) that suppresses ZBP1-mediated cell death by competing for Z-NA binding, revealing alternative splicing as a regulatory mechanism for inflammation.

This study shows that microglial Piezo1 senses Aβ fibril stiffness, influencing AD pathology by affecting phagocytosis and plaque compaction.