Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration
Wei Liu, Song-Ang Wu, Bo-Xin Zhang, Shaoyu Guo, Lang Li, Wenjing Sun, Xushen Xiong, Jiuhong Nan, Jianfeng Wu, Linghui Zeng, Pilong Li, Zhiyu Cai, Huan-Feng Ye, Shuo Zhang, Sheng Nie, , Wei Mo
The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.
bioRxiv · Feb 17, 2026 · PreprintNeuroscience