HIV Nef amplifies mechanical heterogeneity to promote immune evasion
Louise Leyre, Farah Mustapha, Alberto M. Herrera, Esther Lee, Emily M. Huntsman, Paul Zumbo, Jared Weiler, Parul Sinha, Ethan Naing, Connor Smith, Colin C. Kovacs, Michael Galiano, Nada Wahman, Doron Betel, Kiera Clayton, , Richard Brad Jones
This study shows HIV Nef induces a soft phenotype in infected CD4+ T cells, reducing their susceptibility to cytotoxic T lymphocyte killing through cytoskeletal remodeling and intrinsic heterogeneity.
bioRxiv · Dec 26, 2025 · PreprintImmunology