Hyperinflammation evokes different antiviral TMPRSS2 and ADAM17 expression responses in human gut xenograft versus host mouse gut although overall genomic responses are similar
L. Morris, E. Nissim-Eliraz, I. Schouten, F. Bergey, N. Dyer, H. Momiji, E. Nir, N. Marsiano, R. S. Tezerji, S. Yagel, P. Rosenstiel, D. A. Rand, V. A. P. Martins dos Santos, N. Y. Shpigel, SysmedIBD research consortium
This study compares antiviral gene expression responses in human gut xenografts and host mouse gut during hyperinflammation, finding similar genomic responses but species-specific upregulation of TMPRSS2 and ADAM17 in human gut.
bioRxiv · May 9, 2021 · PreprintImmunology