L. Morris

Micronutrient Optimization Using Design of Experiments Approach in Tissue Engineered Articular Cartilage for Production of Type II Collagen

This study uses a Design of Experiments approach with a secreted reporter to optimize micronutrient conditions for enhanced type II collagen expression in engineered cartilage.

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

This study investigates how different isotypes of the same HIV-neutralizing antibody achieve enhanced neutralization potency through distinct mechanisms involving hinge and CH1 regions.

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

This study compares three HIV MPER-targeting antibodies, showing that CAP206-CH12's dependence on a variable residue limits its neutralization breadth, unlike the conserved residue reliance of 4E10 and VRC42.01.

Neutralizing antibodies elicited by the Ad26.COV2.S COVID-19 vaccine show reduced activity against 501Y.V2 (B.1.351), despite protection against severe disease by this variant.

The study assesses neutralizing antibody activity against 501Y.V2 variant post-Ad26.COV2.S vaccination, finding reduced neutralization but potential protection via other immune mechanisms.

Elicitation of neutralizing antibody responses to HIV-1 immunization with nanoparticle vaccine platforms

This study evaluates two nanoparticle vaccine strategies to elicit broadly neutralizing antibodies against HIV-1 by incorporating Env diversity from clade A and C strains, showing neutralization in mice and guinea pigs.

Sequence and functional characterization of a public HIV-specific antibody clonotype

The paper characterizes a public HIV-specific antibody clonotype from three individuals, showing that antigen specificity is modulated by VH germline genes and that non-native heavy-light chain pairings maintain consistent antigen recognition.

Hyperinflammation evokes different antiviral TMPRSS2 and ADAM17 expression responses in human gut xenograft versus host mouse gut although overall genomic responses are similar

This study compares antiviral gene expression responses in human gut xenografts and host mouse gut during hyperinflammation, finding similar genomic responses but species-specific upregulation of TMPRSS2 and ADAM17 in human gut.

SARS-CoV-2 501Y.V2 (B.1.351) elicits cross-reactive neutralizing antibodies

This study examines antibody responses to the SARS-CoV-2 501Y.V2 variant in patients hospitalized in early 2021, finding robust cross-reactivity against earlier variants and the 501Y.V3 variant.

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

This study shows that SARS-CoV-2 501Y.V2 pseudovirus escapes neutralization by South African convalescent plasma but not binding, suggesting potential for reinfection and reduced vaccine efficacy.

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

The paper identifies cross-reactive antibodies against multiple coronaviruses, showing they target diverse epitopes and mediate effector functions.

Population genetics of the coral Acropora millepora: Towards a genomic predictor of bleaching

This study generates a genome assembly for Acropora millepora and identifies genetic predictors of bleaching using genome-wide association analysis.