P. Rosenstiel

This study identifies Nlrp6 as a regulator of DNA repair and epithelial regeneration in intestinal crypts, linking DNA damage responses to colorectal cancer progression.

This study examines how Atg16l1 deletion in intestinal epithelial cells affects fecal microbiota shifts during pregnancy in mice, identifying altered microbial composition and functional potential.

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

This study examines tryptophan wasting across 13 chronic inflammatory diseases, finding reduced serum tryptophan levels and increased kynurenine pathway activity linked to disease activity.

This study shows that E. coli evolves specific genetic and phenotypic traits in an inflamed gut, leading to antibiotic collateral sensitivity and potential therapeutic implications.

This study links amino acid auxotrophies in human gut bacteria to increased microbiome diversity and long-term stability through a combined metabolomic, metagenomic, and metabolic modeling approach.

The paper shows that cyclic severe protein restriction in Drosophila reduces tumor growth, restores gut function, and extends lifespan without the harmful effects of continuous restriction.

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

The paper examines how antibiotic treatment affects the gut virome in mice, finding delayed resilience and correlations between virome and bacteriome shifts.

This study compares antiviral gene expression responses in human gut xenografts and host mouse gut during hyperinflammation, finding similar genomic responses but species-specific upregulation of TMPRSS2 and ADAM17 in human gut.

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

This study shows that blocking peripheral sgp130-mediated trans-signaling in mice causes obesity and insulin resistance by suppressing PPARα.

This study investigates how antibiotic resistance evolves in E. coli under varying erythromycin dosages, finding that resistance increases most rapidly just below the minimal inhibitory concentration.

This paper shows that a high-fat diet increases intestinal stem cell activity in Drosophila, dependent on microbiota and JNK signaling in enterocytes.

The paper identifies a phage-encoded ankyrin domain protein that modulates eukaryotic immune responses, enabling immune evasion in host-microbe interactions.

This study investigates how C. elegans responds to its native microbiome across development and adult life, identifying key molecular processes and regulatory mechanisms.

This study tests the evolutionary stability of collateral sensitivity in Pseudomonas aeruginosa, finding that resistance to one antibiotic often leads to hypersensitivity to another, but evolutionary outcomes depend on drug order.

This study shows that segregational drift in multicopy plasmids reduces their evolvability by increasing mutation loss and fixation time, despite higher mutational supply.