Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data
P. Sahoo, X. Yang, D. Abler, D. Maestrini, V. Adhikarla, D. Frankhouser, H. Cho, V. Machuca, D. Wang, M. Barish, M. Gutova, S. Branciamore, C. E. Brown, R. C. Rockne
This paper uses a mathematical model to analyze CAR T-cell killing dynamics in glioma, showing dose-dependent effects on proliferation and exhaustion.
bioRxiv · Nov 9, 2019Immunology