Author

C. E. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

D. Wang· 3 shared R. C. Rockne· 3 shared X. Yang· 3 shared A. B. Brummer· 2 shared B. Aguilar· 2 shared B. Badie· 2 shared D. Alizadeh· 2 shared H. Cho· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

D. Wang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables

A. B. Brummer, A. Xella, R. Woodall, V. Adhikarla, H. Cho, M. B. Gutova, C. E. Brown, R. C. Rockne

This paper applies sparse identification of non-linear dynamics (SINDy) to discover and interpret CAR T-cell interaction dynamics with glioblastoma cells using latent variables.

bioRxiv · Sep 22, 2022Cancer Biology

Selective IL13Rα2-Targeted Functionality of IL13-Ligand CARs is Enhanced by Inclusion of 4-1BB Co-Stimulation

R. Starr, X. Yang, B. Aguilar, D. Gumber, S. Huard, D. Wang, W.-C. Chang, A. Brito, V. Chiu, J. R. Ostberg, B. Badie, S. J. Forman, D. Alizadeh, L. D. Wang, C. E. Brown

This study compares IL13-ligand CAR designs to determine how co-stimulation domains affect tumor selectivity and anti-tumor activity against glioblastoma.

bioRxiv · Mar 30, 2022 · PreprintImmunology

Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy

A. B. Brummer, X. Yang, E. Ma, M. Gutova, C. E. Brown, R. C. Rockne

This paper uses a mathematical model to show that dexamethasone destabilizes CAR T-cell efficacy in glioblastoma by altering coexistence dynamics and introducing critical thresholds.

bioRxiv · Oct 1, 2021Cancer Biology

CAR T cell therapy drives endogenous locoregional T cell dynamics in a responding patient with glioblastoma

V. D. Jonsson, R. Ng, N. Dullerud, R. A. Wong, J. Hibbard, D. Wang, B. Aguilar, R. Starr, L. Weng, D. Alizadeh, S. Forman, B. Badie, C. E. Brown

This study tracks T cell dynamics in a glioblastoma patient undergoing CAR T cell therapy, showing endogenous T cells are activated and contribute to treatment response.

bioRxiv · Sep 22, 2021 · PreprintImmunology

Spatiotemporal analysis of glioma heterogeneity reveals Col1A1 as an actionable 1 target to disrupt tumor mesenchymal differentiation, invasion and malignancy

A. Comba, S. M. Faisal, P. J. Dunn, A. E. Argento, T. C. Hollon, W. Al-Holou, M. L. Varela, D. B. Zamler, G. L. Quass, P. F. Apostolides, C. Abel, C. E. Brown, P. E. Kish, A. Kahana, C. G. Kleer, , P. R. Lowenstein

The paper identifies COL1A1 as a key driver of glioma mesenchymal differentiation and invasion, showing its inhibition disrupts tumor structure and improves survival.

bioRxiv · Dec 1, 2020 · PreprintCancer Biology

Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

E. Zah, E. Nam, V. Bhuvan, V. T. T. Tran, B. Y. Ji, S. B. Gosliner, X. Wang, C. E. Brown, Y. Y. Chen

This study develops BCMA/CS1 bispecific CAR-T cells that effectively target heterogeneous multiple myeloma, showing improved activity and durable tumor-free survival compared to single-target CAR-T cells.

bioRxiv · Mar 12, 2020Bioengineering

Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data

P. Sahoo, X. Yang, D. Abler, D. Maestrini, V. Adhikarla, D. Frankhouser, H. Cho, V. Machuca, D. Wang, M. Barish, M. Gutova, S. Branciamore, C. E. Brown, R. C. Rockne

This paper uses a mathematical model to analyze CAR T-cell killing dynamics in glioma, showing dose-dependent effects on proliferation and exhaustion.

bioRxiv · Nov 9, 2019Immunology