Orphan quality control shapes network dynamics and gene expression
K. G. Mark, S. Kolla, D. Garshott, B. Martinez-Gonzalez, C. Xu, D. Akopian, D. L. Haakonsen, S. K. See, M. Rape
The paper identifies UBR5 as a quality control enzyme that degrades unpaired transcription factor subunits, shaping network dynamics and gene expression through continuous turnover.
bioRxiv · Nov 6, 2022Biochemistry