Author

M. Rape

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K. G. Mark· 2 shared A. G. Manford· 1 shared B. Martinez-Gonzalez· 1 shared C. Melo-Gavin· 1 shared C. Tan· 1 shared C. Xu· 1 shared D. Akopian· 1 shared D. Garshott· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

K. G. Mark

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Orphan quality control shapes network dynamics and gene expression

K. G. Mark, S. Kolla, D. Garshott, B. Martinez-Gonzalez, C. Xu, D. Akopian, D. L. Haakonsen, S. K. See, M. Rape

The paper identifies UBR5 as a quality control enzyme that degrades unpaired transcription factor subunits, shaping network dynamics and gene expression through continuous turnover.

bioRxiv · Nov 6, 2022Biochemistry

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis

S. Liu, C. Tan, C. Melo-Gavin, M. B. Ginzberg, R. Blutrich, N. Patel, M. Rape, K. G. Mark, R. Kafri

The paper shows oversized cells increase proteasome-mediated protein degradation to maintain size homeostasis by reducing growth efficiency.

bioRxiv · Nov 9, 2021Cell Biology

Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications

N. J. Henning, A. G. Manford, J. N. Spradlin, S. M. Brittain, J. M. McKenna, J. A. Tallarico, M. Schirle, M. Rape, D. K. Nomura

The paper discovers a covalent ligand, EN106, that targets FEM1B for PROTAC-based protein degradation, demonstrating its utility in degrading BRD4.

bioRxiv · Apr 15, 2021Biochemistry