K. G. Mark

Orphan quality control shapes network dynamics and gene expression

The paper identifies UBR5 as a quality control enzyme that degrades unpaired transcription factor subunits, shaping network dynamics and gene expression through continuous turnover.

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis

The paper shows oversized cells increase proteasome-mediated protein degradation to maintain size homeostasis by reducing growth efficiency.