Structural basis of dual BACH1 regulation by SCFFBXO22 and SCFFBXL17
B. Goretzki, M. Khoshouei, P. Penner, C. Stephan, D. Argoti, N. Dierlamm, J. M. Rada, S. Kapps, Z. Thiel, M. Mutlu, D. Furkert, C. S. Müller, F. Freuler, S. Haenni, L. Tenaillon, , C. Fernandez
This study elucidates how BACH1 is regulated by SCFFBXO22 and SCFFBXL17 through structural changes in FBXO22 and modifications in BACH1's BTB domain, affecting its ubiquitylation and stability.
bioRxiv · Jun 3, 2024 · PreprintBiophysics