E. Schmidt

The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly

The paper presents structures of AFPKs from Elysia chlorotica, revealing the ACP linker's role in regulating substrate and product selectivity during polyketide and fatty acid synthesis.

Structural basis of dual BACH1 regulation by SCFFBXO22 and SCFFBXL17

This study elucidates how BACH1 is regulated by SCFFBXO22 and SCFFBXL17 through structural changes in FBXO22 and modifications in BACH1's BTB domain, affecting its ubiquitylation and stability.

Multivalent DNA-encoded lectins on phage enable detecting compositional glycocalyx differences

This paper develops a phage-based liquid lectin array to detect subtle glycocalyx differences by displaying multivalent lectins on DNA-barcoded M13 phage.

Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function.

The paper identifies a cold-inducible truncated Adcy3 mRNA isoform, Adcy3-at, which acts as a rheostat to regulate brown fat function by limiting cAMP activity during obesity.

Apremilast prevents blistering in human epidermis by stabilization of keratinocyte adhesion in pemphigus.

This study shows apremilast stabilizes keratinocyte adhesion in pemphigus by phosphorylating plakoglobin at serine 665, preventing blistering without affecting desmoglein depletion or binding.

Initial efficacy determination and resistance profile of anti-Acinetobacter antibiotics, turnercyclamycins

This study evaluates the efficacy and resistance profile of turnercyclamycins against Acinetobacter, showing high potency and reduced resistance compared to colistin.

Towards an individualised neural assessment of receptive language in children

The paper develops a non-invasive neural test for language comprehension in children using EEG and evaluates its reliability and sensitivity across different paradigms and systems.

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

The paper integrates NMR and cryo-EM to determine the atomic structure of a large enzyme complex, achieving high precision and accuracy beyond the limitations of each method individually.