Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts
M. Berdiel, A. Maia, Z. Hristova, S. Borgoni, M. Vetter, S. Burmester, C. Becki, K. Abnaof, I. Binenbaum, D. Bethmann, A. Chatziioannou, M. Hasmann, C. Thomssen, E. Espinet, S. Wiemann
The paper identifies NRG1-expressing cancer-associated fibroblasts that promote fibrosis and migration through autocrine signaling, independent of HER3, and highlights HAS2 as a targetable molecule.
bioRxiv · Apr 6, 2020Cancer Biology