S. Wiemann

This study shows that T-DM1 induces immunogenic cell death (ICD) in HER2-positive breast cancer, which is lost in resistance, and that targeting TACC3 restores ICD and enhances T-DM1 response.

The paper identifies WNT11 as a novel ligand for ROR2 in breast cancer, showing it promotes invasion through RHO/ROCK signaling and forms an auto-stimulatory loop.

This study identifies miR-193b as a key regulator of WNT/β-catenin, c-Met, and integrin pathways in TNBC, showing its strong repressive effect on metastatic traits.

This study shows chemotherapy-induced IFNβ1 secretion by cancer cells reprograms stromal fibroblasts, promoting breast cancer recurrence through an anti-viral state and pro-inflammatory cytokine expression.

This study identifies ATF3 as a novel mediator of endocrine resistance in breast cancer through time-resolved profiling and validates its role in key signaling pathways and clinical relevance.

The paper identifies NRG1-expressing cancer-associated fibroblasts that promote fibrosis and migration through autocrine signaling, independent of HER3, and highlights HAS2 as a targetable molecule.