Cancer BiologybioRxiv
Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts
M. Berdiel, A. Maia, Z. Hristova…·S. Wiemann
The paper identifies NRG1-expressing cancer-associated fibroblasts that promote fibrosis and migration through autocrine signaling, independent of HER3, and highlights HAS2 as a targetable molecule.
DOI 10.1038/s41388-021-01719-3