Author

E. Espinet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 7 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2

Frequent Co-Authors

A. Trumpp· 5 shared A. Behrendt· 2 shared A. Warth· 2 shared C. P. Heussel· 2 shared C. Plass· 2 shared D. Wyatt· 2 shared E. Donato· 2 shared F. Herth· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCancer Biology

A. Trumpp

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

L. Klein, M. Tu, N. Krebs, L. Urbach, D. G. Grimm, M. U. Latif, F. Penz, N. Chan, K. Aliar, F. Vyas, U. Kishore, E. Hessmann, A. Trumpp, E. Espinet, A. Papantonis, , S. K. Singh

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

bioRxiv · Oct 30, 2023 · PreprintCancer Biology

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

M. L. Prada, U. Schwartz, D. F. Pease, S. T. Pohl, D. Ackesson, R. Li, A. Behrendt, R. Tamas, M. Richter, T. Muley, J. Hey, E. Espinet, C. P. Heussel, A. Warth, M. Schneider, , R. Jurkowska

This study identifies epigenetic changes in AT2 cells from COPD patients that disrupt IFN and WNT pathways, impairing lung regeneration.

bioRxiv · Oct 22, 2023 · PreprintCell Biology

HAPLN1 is a driver for peritoneal carcinomatosis in pancreatic cancer

L. Wiedmann, F. De Angelis Rigotti, N. Vaquero-Siguero, E. Donato, E. Espinet, I. Moll, E. Alsina-Sanchis, R. Mülfarth, M. Vacca, J. Gerwing, A. Trumpp, A. Fischer, J. Rodriguez-Vita

This study identifies HAPLN1 as a driver of peritoneal metastasis in pancreatic cancer by enhancing tumor cell plasticity and immunomodulation.

bioRxiv · May 30, 2022Cancer Biology

Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers

H. Alborzy, Z. Chen, U. Yildiz, F. Porto- Freitas, F. C. E. Vogel, J. Varga, J. Batani, C. Bartenhagen, W. Schmitz, G. Buechel, B. Michalke, J. Zheng, S. Meierjohann, E. Girardi, E. Espinet, , J. P. Friedmann Angeli

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

bioRxiv · May 17, 2022 · PreprintCancer Biology

Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts

M. Berdiel, A. Maia, Z. Hristova, S. Borgoni, M. Vetter, S. Burmester, C. Becki, K. Abnaof, I. Binenbaum, D. Bethmann, A. Chatziioannou, M. Hasmann, C. Thomssen, E. Espinet, S. Wiemann

The paper identifies NRG1-expressing cancer-associated fibroblasts that promote fibrosis and migration through autocrine signaling, independent of HER3, and highlights HAS2 as a targetable molecule.

bioRxiv · Apr 6, 2020Cancer Biology

Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lung.

M. Llamazares Prada, E. Espinet, V. Mijosek, U. Schwartz, S. M. Waszak, P. Lutsik, R. Tamas, M. Richter, A. Behrendt, S. Pohl, N. Benz, T. Muley, A. Warth, C. P. Heussel, H. Winter, , R. Z. Jurkowska

This paper develops a cryopreservation workflow for human lung tissue that maintains cell viability and omics profiles, enabling single-cell and bulk sequencing for studying lung diseases.

bioRxiv · Apr 1, 2020Cell Biology

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

L. Eichelberger, M. Saini, H. D. Moreno, C. Klein, J. M. Bartsch, M. Falcone, M. Reitberger, E. Espinet, V. Vogel, E. Graf, T. Schwarzmayr, T.-M. Strom, M. Lehmann, M. Koenigshoff, N. Pfarr, , C. H. Scheel

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

bioRxiv · Mar 19, 2020 · PreprintCancer Biology