Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH
F. C. Chatelain, N. Gilbert, D. Bichet, A. Jauch, S. Feliciangeli, F. LESAGE, O. Bignucolo
The paper identifies a network of residues responsible for TWIK1 channel's pH-dependent shift in ionic selectivity from K+ to Na+ using MD simulations, mutagenesis, and electrophysiology.
bioRxiv · Nov 9, 2023Biochemistry