Author

F. C. Chatelain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Jauch· 1 shared D. Bichet· 1 shared E. Nematian-Ardestani· 1 shared F. LESAGE· 1 shared H. Sun· 1 shared M. F. Abd-Wahab· 1 shared M. Schewe· 1 shared N. Gilbert· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Jauch

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2 papers

Recent·Most cited

Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH

F. C. Chatelain, N. Gilbert, D. Bichet, A. Jauch, S. Feliciangeli, F. LESAGE, O. Bignucolo

The paper identifies a network of residues responsible for TWIK1 channel's pH-dependent shift in ionic selectivity from K+ to Na+ using MD simulations, mutagenesis, and electrophysiology.

bioRxiv · Nov 9, 2023Biochemistry

Selectivity Filter Instability Dominates the Low Intrinsic Activity of the TWIK-1 K2P K+ Channel

E. Nematian-Ardestani, M. F. Abd-Wahab, F. C. Chatelain, H. Sun, M. Schewe, T. Baukrowitz, S. J. Tucker

This study identifies the instability of the selectivity filter (SF) gate in TWIK-1 K2P channels as the primary cause of their low intrinsic activity.

bioRxiv · Dec 2, 2019Biophysics