N. Gilbert

Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice

This study shows that SLPI protects against acute UTI in mice and suggests SLPI is regulated in response to uropathogen exposure in women.

Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH

The paper identifies a network of residues responsible for TWIK1 channel's pH-dependent shift in ionic selectivity from K+ to Na+ using MD simulations, mutagenesis, and electrophysiology.

Bridging-mediated compaction of mitotic chromosomes

This paper uses simulations to show bridging factors create mitotic-like chromosome structures without energy input, matching experimental observations.

Condensin reorganizes centromeric chromatin during mitotic entry into a bipartite structure stabilized by cohesin

This study shows vertebrate centromeres form a bipartite structure during mitosis, stabilized by condensin and linked by cohesin, which prevents merotelic attachments and chromosomal instability.

Transcription modulates chromatin dynamics and locus configuration sampling

The paper uses simulations and experiments to show transcription affects chromatin dynamics and locus configurations in mouse cells.

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

This study shows that 3D genome organization leads to complex small-world regulatory networks and stochastic transcription, explaining how GWAS results align with overexpression experiments.

SAF-A promotes origin licensing and replication fork progression to ensure robust DNA replication

This study shows SAF-A promotes DNA replication by enhancing origin licensing and fork progression, preventing replication defects and cell quiescence.

Glycan cross-feeding drives mutualism between Fusobacterium and the vaginal microbiota

This study shows that sialidase activity enables Fusobacterium to exploit sialoglycans, promoting its colonization and mutualistic interactions with the vaginal microbiota, which contributes to dysbiosis.