Author

D. Castel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Burford· 1 shared A. Mackay· 1 shared A. Sottoriva· 1 shared C. Jones· 1 shared C. Silva-Evangelista· 1 shared C. Subecz· 1 shared E. Oberlin· 1 shared E. Yara-Romero· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Burford

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

VRK3 depletion induces cell cycle arrest and metabolic reprogramming of Pontine Diffuse Midline Glioma (DMG)-K27 altered cells

V. Menez, T. Kergrohen, T. Sasha, C. Silva-Evangelista, L. Ledret, L. Auffret, C. Subecz, M. Lancien, Y. Ajlil, K. Beccaria, T. Blauwblomme, E. Oberlin, J. Grill, D. Castel, M.-A. Debily

This study shows VRK3 depletion causes cell cycle arrest and metabolic reprogramming in DMG-K27M cells, with potential therapeutic implications.

bioRxiv · Mar 24, 2023 · PreprintCancer Biology

Loss of the H4 lysine methyltransferase KMT5B drives tumorigenic phenotypes by depleting H3K27me3 at loci otherwise retained in H3K27M mutant DIPG cells

K. Kessler, A. Mackay, Y. Grabovska, V. Molinari, A. Burford, S. Temelso, H. Tari, E. Yara-Romero, I. Liu, L. Yu, D. Castel, J. Choudhary, A. Sottoriva, M. Filbin, M. Vinci, C. Jones

The paper shows that loss of KMT5B in DIPG cells depletes retained H3K27me3 loci, leading to transcriptional changes that promote tumorigenesis.

bioRxiv · Jul 19, 2021 · PreprintCancer Biology