Hypercapnia limits β-catenin mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts
L. A. Dada, L. C. Welch, N. D. Magnani, Z. Ren, P. L. Brazee, D. Celli, A. S. Flozak, A. Weng, M. Maciel-Herrerias, V. Kryvenko, I. Vadasz, C. E. Runyan, H. Abdala-Valencia, M. Shigemura, S. M. Casalino-Matsuda, , J. I. Sznajder
This study shows hypercapnia inhibits β-catenin signaling in alveolar type 2 cells by altering Wnt production from fibroblasts, impairing lung repair after injury.
bioRxiv · Jan 12, 2022 · PreprintCell Biology