Z. Ren

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATION

This study shows that dopamine D4 receptor reduces NCC protein levels by promoting its ubiquitination and lysosomal degradation in mice.

Short-chain carboxylates facilitate the counting of yeasts in Sub-high temperature Daqu.

This study investigates the use of short-chain carboxylates to selectively inhibit mold growth in Sub-high temperature Daqu, improving yeast counting efficiency.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo

This study investigates the robustness and dynamics of Min protein oscillations in E. coli, showing their optimal expression levels and complex patterns under varying conditions.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Theranostic gold in a gold cage nanoparticle for photothermal ablation and photoacoustic imaging of skin and oral infections

This study develops a theranostic gold nanoparticle for detecting and treating biofilm infections using photothermal ablation and photoacoustic imaging, showing superior efficacy against oral and wound infections compared to chlorhexidine.

Using DNA flow-stretching assay as a tool to validate the tagging of DNA-binding proteins for single-molecule experiments

This paper uses a DNA flow-stretching assay to evaluate how a KCK tag affects DNA-binding protein behavior in single-molecule experiments.

Crosstalk in skin: Loss of desmoglein 1 in keratinocytes inhibits BRAFV600E-induced cellular senescence in human melanocytes

The paper shows that loss of desmoglein 1 in keratinocytes reduces senescence in BRAFV600E-expressing melanocytes by promoting NTN4 expression.

Spin-coupled electron densities of iron-sulfur cluster imaged by in situ serial Laue diffraction

The paper uses in situ serial Laue diffraction to image spin-coupled electron densities in a [4Fe4S] iron-sulfur cluster during light-induced redox reactions.

ATM-Mediated Double-Strand Break Repair Is Required for Meiotic Genome Stability at High Temperature

This study shows ATM is essential for maintaining meiotic genome stability in Arabidopsis at high temperatures, acting through the MRN complex and chromosome axis, independent of RAD51.

Redox signaling regulates breast cancer metastasis via HIF1alpha-stimulated EMT dynamics and metabolic reprogramming

This study shows that GPx2 loss in mammary tumors enhances metastasis through HIF1-driven EMT and metabolic changes, identified via scRNA-seq.

Nanosecond pulsed electric field ablates rabbit VX2 liver tumors in a non-thermal manner versus radiofrequency ablation

This study compares nanosecond pulsed electric field (nsPEF) and radiofrequency ablation (RFA) in treating rabbit VX2 liver tumors, showing nsPEF induces apoptosis and non-thermal ablation.

CircRNA-regulated immune response of Asian honey bee workers to microsporidian infection

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

Inhibitory effects of GT0918 on acute lung injury and the molecular mechanisms of anti-inflammatory response

This study shows GT0918 reduces cytokine release and inflammation in COVID-19 by inhibiting NF-κB and activating NRF2, suggesting its potential for treating both mild and severe cases.

Transcriptomic analysis reveals hub genes and pathways in response to acetic acid stress in Kluyveromyces marxianus during high-temperature ethanol fermentation

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

Roles of RodZ and Class A PBP1b in the Assembly and Regulation of the Peripheral Peptidoglycan Elongasome in Ovoid-Shaped Cells of Streptococcus pneumoniae D39

This study investigates the role of RodZ and PBP1b in the PG elongasome of ovoid-shaped Streptococcus pneumoniae, showing RodZ as a scaffolding protein and PBP1b's involvement in elongasome regulation.

De-heterogeneity of the eukaryotic viral reference database (EVRD) improves the accuracy and efficiency of viromic analysis

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

ECD of PepT1 interacts with TM1 to facilitate substrate transport

The paper reports the structure of PepT1 from horse, showing the extracellular domain (ECD) interacts with TM1 and bridges N- and C-domains, with ECD deletion or mutations impairing transport activity.

Hypercapnia limits β-catenin mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts

This study shows hypercapnia inhibits β-catenin signaling in alveolar type 2 cells by altering Wnt production from fibroblasts, impairing lung repair after injury.

Stem embolism vulnerability curve depends on methods used: is there a fifth mechanism of cavitation?

This paper investigates how different methods for measuring stem embolism vulnerability affect results, finding that nano-particles may induce early cavitation and that the origin of these particles might be from living cells near vessels.

Insight into the mechanism of H+-coupled nucleobase transport

The paper reports the structure and function of PurTCp, a NAT family transporter from Colwellia psychrerythraea, showing it transports purines via H+-dependent mechanism and identifies a critical aspartate residue.

Interfered Chromosome Pairing Promotes Meiosis Instability of Autotetraploid Arabidopsis by High Temperatures

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

Directional proton conductance in bacteriorhodopsin is driven by concentration gradient, not affinity gradient

This study shows that directional proton conductance in bacteriorhodopsin is driven by a steep proton concentration gradient, not by changes in proton affinity.

Photoinduced isomerization sampling of retinal in bacteriorhodopsin

The paper reports the deconvolution of early photoproducts in bacteriorhodopsin using time-resolved serial crystallography, revealing isomerization sampling of retinal before the productive 13-cis configuration.

Abundant and rare bacterial taxa structuring differently in sediment and water in thermokarst lakes in the Yellow River Source area, Qinghai-Tibet Plateau

This study compares bacterial communities in sediment and water of thermokarst lakes, finding distinct differences in diversity and community structure, with rare taxa showing stronger environmental structuring.

The Magnaporthe oryzae MAP kinase Pmk1 regulates polycomb repressive complex 2 to reprogram genes expression for biotrophic growth

This paper identifies PRC2-mediated epigenetic repression as critical for regulating gene expression during biotrophic growth in M. oryzae, with Pmk1 coordinating this process by modulating Suz12.

A chloride efflux transporter OsBIRG1 regulates grain size and salt tolerance in rice

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

Catch and kill airborne SARS-CoV-2 to control spread of COVID-19 by a heated air disinfection system

Heated Ni-foam filters effectively catch and kill airborne SARS-CoV-2 and Bacillus anthracis spores.

DNA-loop extruding SMC complexes can traverse one another in vivo

This study investigates how SMC complexes interact when encountering each other on DNA, showing they can traverse, leading to chromosome reorganization and bypassing steric barriers.