Author

D. Christini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. P. Clark· 2 shared T. Krogh-Madsen· 2 shared K. E. Fullerton· 1 shared K. Fullerton· 1 shared S. Wei· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersPhysiology

A. P. Clark

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Optimization of a Cardiomyocyte Model Illuminates Role of Increased INaL in Repolarization Reserve

K. E. Fullerton, A. P. Clark, T. Krogh-Madsen, D. Christini

This paper optimizes a cardiomyocyte model using a genetic algorithm to enhance repolarization reserve, revealing an unexpected role of increased late sodium current in maintaining action potential stability.

bioRxiv · Aug 31, 2023 · PreprintPhysiology

Rapid ionic current phenotyping (RICP) identifies mechanistic underpinnings of iPSC-CM AP heterogeneity

A. P. Clark, S. Wei, K. Fullerton, T. Krogh-Madsen, D. Christini

This study introduces RICP to quantify ionic current heterogeneity in iPSC-CMs and identifies key currents determining action potential variability.

bioRxiv · Aug 16, 2023 · PreprintBioengineering