S. Wei

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Renalase inhibition regulates β cell metabolism to defend against acute and chronic stress

This study shows that inhibiting Renalase protects β cells from stress by shifting metabolism towards glycolysis and GSH synthesis in both mice and humans.

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 Diabetes Mellitus Rats

This study shows that Grifola frondosa polysaccharide reduces inflammation and insulin resistance in T2DM rats by modulating liver macrophage polarization.

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

Beta Cells Deficient for Renalase Counteract Autoimmunity by Shaping Natural Killer Cell Activity

This study shows that beta cells lacking Renalase reduce autoimmunity by altering Natural Killer cell activity and enhancing anti-inflammatory responses.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication.

The paper identifies bi-directionally expressed enhancers in maize with domestication signatures using integrated epigenomic and transcriptomic data from multiple tissues and inbred lines.

Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells

This study shows thyroid hormone promotes differentiation of medulloblastoma cells, reducing tumor growth by reversing EZH2-mediated repression of NeuroD1.

Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

This study uses single-cell transcriptomics to identify cell type-specific immune responses in a mouse model of allergic contact dermatitis, highlighting the role of dermal fibroblasts in type-1 inflammation.

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

The origin, deployment, and evolution of a plant-parasitic nematode effectorome

This study identifies and characterizes the effectorome of the plant-parasitic nematode Heterodera schachtii, revealing 659 effector gene loci and providing insights into their origin, deployment, and evolution.

A comprehensive landscape of the zinc-regulated human proteome

This study maps zinc-regulated cysteine sites in the human proteome, identifies cancer dependencies, and reveals a mechanism of zinc-induced cytotoxicity in lung cancers.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.

The paper analyzes molecular differences in ductal carcinoma in situ (DCIS) by self-reported race and outcome groups, identifying variations in gene expression, tumor microenvironment, and copy number variations between Black and White women.

Rapid ionic current phenotyping (RICP) identifies mechanistic underpinnings of iPSC-CM AP heterogeneity

This study introduces RICP to quantify ionic current heterogeneity in iPSC-CMs and identifies key currents determining action potential variability.

Prognostic Gene Signature for lung adenocarcinoma with a Higher Risk for Treatment Failure and Accelerated cell cycle and cell proliferation Pathway Activity

The paper identifies a 78-gene prognostic signature for lung adenocarcinoma that correlates with cell cycle activity and treatment response to PIM inhibitors.

The ecological characteristics of the safe sites for early-stage establishment of Chamaecyparis obtusa var. formosana seedlings in Taiwan

This study identifies environmental and biotic factors affecting the establishment of Chamaecyparis obtusa var. formosana seedlings in Taiwan, finding that decayed coarse wood debris provides a 'safe site' for seedling survival.

A nanobody-based strategy for rapid and scalable purification of native human protein complexes

This paper introduces a method for rapidly purifying native human protein complexes using nanobodies and lentiviral transduction, achieving high purity and yield in ~8 days.

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

This paper shows seal-leak current affects iPSC-CM action potential morphology even with high seal resistance, and suggests ways to improve data interpretation and modeling.

Targeted Protein Degradation via Nanoparticles

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

A low-cost and open-source solution to automate imaging and analysis of cyst nematode infection assays for Arabidopsis thaliana

The paper presents a low-cost, open-source imaging and analysis system for automated nematode infection phenotyping in Arabidopsis thaliana.

High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling

This paper introduces a platform integrating phenotypic screening and metabolomics to improve mechanism of action prediction for natural products, leading to the discovery of novel bioactive compounds.

Identification and calibration of ultrabright localizations to eliminate quantification error in SMLM

This paper identifies and calibrates ultrabright localizations in SMLM to improve quantification accuracy for biomolecular organization.

Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat generated by CRISPR/Cas9

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

Reactive Oxygen Species-induced Protein Carbonylation Promotes Deterioration of Physiological Activity of Wheat Seeds

This study examines how reactive oxygen species-induced protein carbonylation reduces wheat seed vigor during aging by correlating carbonyl protein content with seed vitality and structural changes.

A model-guided pipeline for drug cardiotoxicity screening with human stem-cell derived cardiomyocytes

This study develops an in vitro-in silico pipeline using iPSC-CMs to screen for drug cardiotoxicity by evaluating proarrhythmia risk and ion channel block mechanisms.

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

Identifying Upper Airway and Evaluating Adenoid in Lateral Cephalometric Radiographs of Pediatric Patients Using Image-based Deep Learning Technique

This paper develops a deep learning system to assess upper airway obstruction and adenoid size in pediatric radiographs, achieving good segmentation performance and agreement with experts.

Artificial selection of stable rhizosphere microbiota leads to heritable plant phenotype changes

Artificial selection of rhizosphere microbiota in Brachypodium distachyon leads to heritable changes in leaf greenness.

Application of an integrated computational antibody engineering platform to design SARS-CoV-2 neutralizers

The paper designs SARS-CoV-2 neutralizing antibodies using a computational platform to improve binding affinity and developability, and introduces trispecific formats and Fc modifications to enhance efficacy and reduce risk.