Ageing-related defects in macrophage function are driven by MYC and USF1 transcriptional programmes
C. E. Moss, S. Johnston, M. Clements, V. Codd, S. Hamby, A. H. Goodall, S. Desmukh, I. M. Sudbery, D. Coca, H. L. Wilson, E. Kiss-Toth
This study identifies MYC and USF1 as key drivers of age-related functional decline in human macrophages, showing their role in phagocytosis, migration, and morphology.
bioRxiv · Sep 20, 2023 · PreprintImmunology