Author

M. Clements

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Bailey· 1 shared A. Dubrovskiy· 1 shared A. H. Goodall· 1 shared A. Local· 1 shared A. Martinez-Segura· 1 shared A. P. Gould· 1 shared A. Shakya· 1 shared C. E. Moss· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bailey

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ageing-related defects in macrophage function are driven by MYC and USF1 transcriptional programmes

C. E. Moss, S. Johnston, M. Clements, V. Codd, S. Hamby, A. H. Goodall, S. Desmukh, I. M. Sudbery, D. Coca, H. L. Wilson, E. Kiss-Toth

This study identifies MYC and USF1 as key drivers of age-related functional decline in human macrophages, showing their role in phagocytosis, migration, and morphology.

bioRxiv · Sep 20, 2023 · PreprintImmunology

Diet suppresses tumour initiation by maintaining quiescence of mutation-bearing neural stem cells

V. Amodeo, T. Davies, A. Martinez-Segura, M. Clements, H. Simpson Ragdale, A. Bailey, M. Silva dos Santos, J. I. MacRae, J. Mokochinski, H. Kramer, C. Garcia-Diaz, A. P. Gould, S. Marguerat, S. Parrinello

This study shows that diet can suppress glioblastoma by restoring quiescence in p53-deficient neural stem cells through omega-3 fatty acids.

bioRxiv · Mar 9, 2022 · PreprintCancer Biology

An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

T. Dahlen, M. Clements, J. Zhao, M. Olsson, G. Edgren

This study investigates associations between ABO and RhD blood groups and a wide range of diseases using a large population dataset, identifying 49 and 1 significant associations after adjustment.

eLife · Apr 27, 2021Peer-reviewedPhysiology

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.

S. A. Saenz, A. Local, T. Carr, A. Shakya, S. Koul, H. Hu, L. Chourb, J. Stedman, J. Malley, L. A. DAgostino, V. Shanmugasundaram, J. Malona, C. E. Schwartz, L. Beebe, M. Clements, , J. M. Ellis

The paper develops three RORγt inhibitors that reduce Th17 differentiation and inflammation in vivo and inhibit tumor growth in PDAC organoids.

bioRxiv · Feb 19, 2021 · PreprintImmunology