Impaired Therapeutic Efficacy of Bone Marrow Cells from Post-Myocardial Infarction Patients in the TIME and LateTIME Clinical Trials
X. Wang, R. Derakhshandeh, H. J. Rodriguez, D. D. Han, D. S. Kostyushev, T. D. Henry, J. H. Traverse, L. Moye, R. D. Simari, D. A. Taylor, M. L. Springer
The paper tests if post-MI human MNCs from clinical trials show impaired therapeutic efficacy compared to healthy donor MNCs in mouse models, finding no therapeutic benefit in either TIME or LateTIME patient MNCs.
bioRxiv · Aug 1, 2019Physiology