Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase
J. O. Matos, R. P. Kumar, A. C. Ma, M. Patterson, I. J. Krauss, D. D. Oprian
The paper elucidates the mechanism of anti-Markovnikov addition in pentalenene synthase by solving crystal structures and showing how residue F76 stabilizes the carbocation through cation-π interactions.
bioRxiv · Jun 17, 2020Biochemistry