Author

M. Patterson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2 Microbiology· 2 Animal Behavior & Cognition· 1 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Organism:mouse· 2 Research Focus:phylogenetics / evolution· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

D. D. Oprian· 2 shared G. Della Vedova· 2 shared I. J. Krauss· 2 shared J. O. Matos· 2 shared P. Bonizzoni· 2 shared S. Ciccolella· 2 shared A. Byun· 1 shared A. C. Ma· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiochemistry

D. D. Oprian

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Author profile →

10 papers

Recent·Most cited

Crystal Structure of Caryolan-1-ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction

P. K. Ramasamy, J. O. Matos, B. Y. Black, W. H. Ellenburg, J. Chen, M. Patterson, J. A. Gehtman, D. Theobald, I. J. Krauss, D. D. Oprian

The paper solves the crystal structure of caryolan-1-ol synthase with and without a substrate analog, revealing structural changes that suggest a mechanism for anti-Markovnikov cyclization.

bioRxiv · May 4, 2024Biochemistry

Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes

M. Flinn, S. Alvarez-Argote, M. C. Knas, V. Alencar, S. J. Paddock, X. Zhou, T. Buddell, A. Jamal, P. Liu, J. Drnevich, M. Patterson, B. Link, C. C. O'Meara

This study shows that Yap and Wwtr1 regulate Ccn3 in cardiac myofibroblasts, and their depletion reduces fibrosis and improves cardiac function after myocardial infarction.

bioRxiv · Dec 1, 2022Physiology

Felidae call type and species identification based on acoustic features

D. Bandara, K. Exantus, C. Navarro-Martinez, M. Patterson, A. Byun

This study develops a machine learning approach to classify felid calls and identify distinguishing acoustic features, achieving 91% accuracy for call type and 86% for species classification within Pantherinae.

bioRxiv · Mar 30, 2022 · PreprintAnimal Behavior & Cognition

Molecular basis of DNA recognition by the HMG-box-C1 module of Capicua

J. Webb, A. D. Gnann, J. J. M. Liew, M. Patterson, S. Paul, M. Fores, G. Jimenez, A. Veraksa, D. P. Dowling

This study determines the crystal structure of the CIC HMG-box and C1 domains bound to DNA, revealing their cooperative role in DNA recognition and how mutations disrupt this mechanism.

bioRxiv · Mar 28, 2022Biochemistry

Machupo virus with mutations in the transmembrane domain and glycosylation sites is attenuated and immunogenic in animal models of Bolivian Hemorrhagic Fever

E. Mantlo, J. Maruyama, J. T. Manning, T. G. Wanninger, C. Huang, J. N. Smith, M. Patterson, S. Paessler, T. Koma

This paper attenuates Machupo virus by mutating glycosylation sites and a transmembrane domain residue, showing attenuation in animal models and protective efficacy against wild-type virus.

bioRxiv · Dec 2, 2021 · PreprintMicrobiology

Effective clustering for single cell sequencing cancer data

S. Ciccolella, M. Patterson, P. Bonizzoni, G. Della Vedova

This paper introduces a clustering method for single-cell sequencing cancer data, improving runtime and scalability while maintaining accuracy in phylogenetic inference.

bioRxiv · May 14, 2021Cancer Biology

Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase

J. O. Matos, R. P. Kumar, A. C. Ma, M. Patterson, I. J. Krauss, D. D. Oprian

The paper elucidates the mechanism of anti-Markovnikov addition in pentalenene synthase by solving crystal structures and showing how residue F76 stabilizes the carbocation through cation-π interactions.

bioRxiv · Jun 17, 2020Biochemistry

An Open-Source Plate Reader

K. Szymula, M. S. Magaraci, M. Patterson, A. Clark, S. G. Mannickarottu, B. Y. Chow

The paper describes the design and benchmarking of an open-source microplate reader with spectrophotometric and fluorescence detection capabilities.

bioRxiv · Sep 12, 2018Bioengineering

gpps: An ILP-based approach for inferring cancer progression with mutation losses from single cell data

S. Ciccolella, M. Soto Gomez, M. Patterson, G. Della Vedova, I. Hajirasouliha, P. Bonizzoni

gpps infers cancer progression from single-cell data by allowing mutation losses, improving upon traditional methods that assume mutations are irreversible.

bioRxiv · Sep 4, 2018Cancer Biology

High-risk human papillomaviruses down-regulate expression of the Ste20 family kinase MST1 to inhibit the Hippo pathway and promote transformation

E. Morgan, M. Patterson, S. Y. Lee, C. Wasson, A. Macdonald

This study shows that high-risk HPV downregulates MST1, inactivating the Hippo pathway and promoting cervical cancer transformation.

bioRxiv · Jul 14, 2018 · PreprintMicrobiology