Senescent cell-derived extracellular vesicles inhibit cancer recurrence by coordinating immune surveillance
T. Ziglari, N. Calistri, J. M. Finan, D. Derrick, E. S. Nakayasu, M. Burnet, J. E. Kyle, M. W. Hoare, L. Heiser, F. Pucci
This study shows senescent cell-derived extracellular vesicles (senEVs) suppress tumor growth by coordinating immune surveillance, specifically by recruiting MHC-II+ antigen-presenting cells and activating CCR2+ TH17 cells.
bioRxiv · Jun 30, 2022Cancer Biology