Author

L. Heiser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

N. Calistri· 2 shared B. Wehrle-Haller· 1 shared C. Betts· 1 shared C. J. Daniel· 1 shared C. M. Franz· 1 shared C. Pelz· 1 shared D. Derrick· 1 shared E. Bucher· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

N. Calistri

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Novel Mouse Model that Recapitulates the Heterogeneity of Human Triple Negative Breast Cancer

Z. O. Doha, X. Wang, N. Calistri, J. Eng, C. J. Daniel, L. Ternes, E. N. Kim, C. Pelz, M. Munks, C. Betts, N. Kirchberger, S. Kwon, E. Bucher, X. Li, T. Waugh, , R. C. Sears

This paper develops a novel mouse model of TNBC by combining MYC amplification and PTEN deletion, showing it recapitulates human TNBC heterogeneity through omic analyses.

bioRxiv · Oct 7, 2022 · PreprintCancer Biology

Senescent cell-derived extracellular vesicles inhibit cancer recurrence by coordinating immune surveillance

T. Ziglari, N. Calistri, J. M. Finan, D. Derrick, E. S. Nakayasu, M. Burnet, J. E. Kyle, M. W. Hoare, L. Heiser, F. Pucci

This study shows senescent cell-derived extracellular vesicles (senEVs) suppress tumor growth by coordinating immune surveillance, specifically by recruiting MHC-II+ antigen-presenting cells and activating CCR2+ TH17 cells.

bioRxiv · Jun 30, 2022Cancer Biology

Ligand binding promiscuity of αVβ3 integrin is enlarged in response to mechanical force

M. Bachmann, M. Schäfer, V. Mykuliak, M. Ripamonti, L. Heiser, K. Weissenbruch, S. Krübel, C. M. Franz, V. Hytönen, B. Wehrle-Haller, M. Bastmeyer

This study shows that mechanical force increases the ligand promiscuity of αVβ3 integrin by enabling binding to fibronectin through conformational changes.

bioRxiv · Nov 20, 2018Cell Biology