Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using D-Alanine Auxotrophy
T. M. Whitfill, D. Dodds, J. L. Bose, M.-D. Dong, G. Dube, T. Grossman, A. Kaiser, K. Kulkarni, R. Leger, S. Mootien-Boyd, A. Munivar, J. Oh, M. Pestrak, K. Rajpura, A. Tikhonov, T. Turecek
This paper engineers a D-alanine auxotrophic strain of S. epidermidis that can be controlled for therapeutic use on the skin without antibiotics or resistance genes.
bioRxiv · Mar 10, 2020Microbiology