J. Oh

Genotype-environment-driven dysbiosis in the skin microbiome of ichthyosis

This study shows that ichthyosis genotype, phenotype, and host factors influence the skin microbiome's species, strain, and metabolic pathway composition.

Probing the glioma micro-environment: analysis using biopsy in combination with ultra-fast cyclic immunolabeling

This study develops a repeat-biopsy model in mice combined with ultra-fast cycling technology to analyze immune response changes in gliomas over time and in response to treatment.

Native Korean wild mice (Mus musculus): molecular phylogeny and morphometrics

The paper analyzes genetic and morphological data of Korean wild mice to determine their phylogenetic relationships and taxonomic status within the Mus musculus subspecies.

APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranes

The paper shows APP and Aβ-peptides modulate protein aggregation and DCG biogenesis in Drosophila cells, with mutant Aβ-peptides disrupting these processes and causing AD-like pathologies.

Species- and strain-effects in interferon, innate immunity, and barrier transcriptional response of microbiome interactions of 3D respiratory epithelial cultures

The paper examines how different microbes affect host immune and barrier responses in respiratory epithelial cultures, finding that interferon variability is not linked to microbial diversity or other innate pathways.

Elf1 promotes Rad26 interaction with lesion-arrested Pol II for transcription-coupled repair

The paper investigates how Rad26 interacts with lesion-arrested Pol II and identifies Elf1's role in enhancing this interaction for transcription-coupled repair.

A simple solid media assay for detection of synergy between bacteriophages and antibiotics

The paper develops a solid media assay to assess synergistic interactions between antibiotics and bacteriophages, identifying synergistic effects across diverse bacterial isolates.

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

Jumbo phages are active against extensively-drug-resistant eyedrop-associated Pseudomonas aeruginosa infections.

The paper identifies jumbo and non-jumbo phages effective against XDR Pseudomonas aeruginosa isolates causing eyedrop-associated infections.

IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation

This study shows IL-10 limits inflammation by restricting sphingolipid metabolism through fatty acid desaturation, with metabolic correction reducing inflammation in IL-10-deficient macrophages.

High-Throughput Bioprinting of the Nasal Epithelium using Patient-derived Nasal Epithelial Cells

This study uses 3D bioprinting to create nasal epithelium models from patient-derived cells, enabling high-throughput fabrication and recapitulating native epithelial architecture and virus infection capability.

Microbiome modulates immunotherapy response in cutaneous squamous cell carcinoma

This study shows that the skin microbiome affects the response to anti-PD1 immunotherapy in squamous cell carcinoma by using antibiotic-induced microbiome depletion in mice.

SPNS1 is required for the transport of lysosphingolipids and lysoglycerophospholipids from lysosomes

This study identifies SPNS1 as a lysosomal transporter critical for exporting lysosphingolipids and lysoglycerophospholipids, linking its deficiency to lysosomal storage disease-like pathology.

Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion

The paper identifies distinct super-enhancer elements that differentially regulate Il2ra expression in DN2/DN3 thymocytes and Treg cells versus mature T and NK cells.

Antiviral immune response reveals host-specific virus infections in natural ant populations

The paper identifies host-specific viruses in ant populations using RNA-seq and sRNA-seq, revealing high host-specificity of active infections and spillover of non-infecting contaminants.

Embryonic Vitamin D Deficiency Programs Hematopoietic Stem Cells to Induce Type 2 Diabetes

The paper shows that embryonic vitamin D deficiency in HSCs leads to diabetes in mice by altering epigenetic pathways and macrophage function.

scoMorphoFISH: A Deep-Learning enabled toolbox for single-cell single-mRNA quantification and correlative (ultra-)morphometry

scoMorphoFISH provides a deep-learning tool for spatial single-cell mRNA quantification and morphometry in kidney biopsies, enabling single-mRNA resolution analysis.

NSMCE2, a Novel Super-Enhancer Regulated Gene, is Linked to Poor Prognosis and Therapy Resistance in Breast Cancer

This study identifies NSMCE2 as a super-enhancer regulated gene linked to poor prognosis and therapy resistance in breast cancer, showing that targeting it can enhance chemotherapy effectiveness.

Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses

This study develops a hybrid vaccine combining influenza VLPs with SARS-CoV-2 RBD and GM-CSF, showing protection against both viruses in mice.

Accumulation of Treg cells is detrimental in late-onset (aged) mouse model of multiple sclerosis

This study shows that accumulated Treg cells in aged mice worsen experimental autoimmune encephalomyelitis (EAE) by disrupting Treg/Teff balance and impairing CNS immune cell trafficking.

In vitro validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapy

The paper validates a neoantigen prediction algorithm, Neopepsee, by testing its immunogenicity using ELISpot assays on patient-derived samples and compares it to pVACseq.

Multi-omics of host-microbiome interactions in short- and long-term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

This study uses multi-omics analyses to compare short- and long-term ME/CFS patients with healthy controls, identifying microbiome and metabolic differences and potential biomarkers.

Mice with a humanized immune system are resilient to transplantation of human microbiota

This study shows that humanized mice with engrafted human immune cells can resist human gut microbes, but microbial communities differ from those in non-humanized mice.

Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation

The paper develops a cell-adaptable hydrogel with stem cells to improve spinal cord injury repair by reducing neuroinflammation and enhancing axonal growth in rats.

Large-scale CRISPRi and transcriptomics of Staphylococcus epidermidis identify genetic factors implicated in commensal-pathogen lifestyle versatility

This study uses CRISPRi and transcriptomics to identify genetic factors in S. epidermidis that contribute to its commensal and pathogenic lifestyle versatility across diverse environments.

Species and strain cultivation of skin, oral, and gut microbiota

The paper describes a workflow for cultivating skin, oral, and gut microbes using metagenomic data and validates its effectiveness.

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

Thymic rejuvenation via induced thymic epithelial cells (iTECs) from FOXN1-overexpressing fibroblasts to counteract inflammaging

This paper demonstrates that induced thymic epithelial cells (iTECs) from FOXN1-overexpressing fibroblasts can rejuvenate aged thymus and reduce inflammaging in mice.

Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using D-Alanine Auxotrophy

This paper engineers a D-alanine auxotrophic strain of S. epidermidis that can be controlled for therapeutic use on the skin without antibiotics or resistance genes.

An enhanced characterization of the human skin microbiome: a new biodiversity of microbial interactions

This study improves characterization of the human skin microbiome by combining reference-based and de novo methods, revealing higher biodiversity and lower stability in skin sites.