Author

D. E. Kirschner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Pharmacology & Toxicology· 1

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Research Focus:host-pathogen & immune response· 3 Organism:non-human primate· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. L. Flynn· 4 shared H. J. Borish· 3 shared J. J. Linderman· 3 shared A. G. White· 2 shared J. Tomko· 2 shared L. J. Frye· 2 shared L. R. Joslyn· 2 shared P. L. Lin· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

J. L. Flynn

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4 papers

Recent·Most cited

Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens

M. Budak, J. M. Cicchese, P. Maiello, H. J. Borish, A. G. White, H. B. Chishti, J. Tomko, L. J. Frye, D. Fillmore, K. Kracinovsky, J. Sakal, C. A. Scanga, P. L. Lin, V. Dartois, J. J. Linderman, , D. E. Kirschner

This study compares standard TB treatment with moxifloxacin-containing regimens using computational models and experimental validation to identify more effective and patient-friendly treatment options.

bioRxiv · Dec 18, 2022Pharmacology & Toxicology

Concomitant immunity to M. tuberculosis infection

L. R. Joslyn, J. L. Flynn, D. E. Kirschner, J. J. Linderman

This study uses a virtual host model to predict that concomitant immunity against M. tuberculosis is linked to tissue-resident memory T cells, with an estimated lifespan of 2-3 years in human lung tissue.

bioRxiv · Aug 2, 2022Immunology

T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

N. L. Grant, P. Maiello, E. Klein, P. L. Lin, H. J. Borish, J. Tomko, L. J. Frye, A. G. White, D. E. Kirschner, J. T. Mattila, J. L. Flynn

This study tracks T cell transcription factor expression in granulomas of Mtb-infected macaques over time, showing increased T-bet+ T cells correlate with reduced bacterial burden.

bioRxiv · Jan 25, 2022 · PreprintImmunology

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

T. Wessler, L. R. Joslyn, H. J. Borish, H. P. Gideon, J. L. Flynn, D. E. Kirschner, J. J. Linderman

This paper develops a computational model to simulate Mtb infection in lungs and identifies factors that prevent bacterial dissemination.

bioRxiv · Jul 24, 2019Immunology